Different contractile mechanism produced by 6-OHDA and 5-OHDA in rabbit pulmonary artery
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Catechin attenuates behavioral neurotoxicity induced by 6-OHDA in rats
This study was designed to investigate the beneficial effect of catechin in a model of Parkinson's disease. Unilateral, intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were pretreated with catechin (10 and 30 mg/kg) by intraperitoneal (i.p.) injection 2h before surgery and for 14 days afterwards. After treatments, apomorphine-induced rotations, locomotor activity, working memory and earl...
متن کاملHEART FUNCTION AND ATPase AFTER 6-OHDA/Dowell
2. Genes LS: Elcctrophysiologic Basis of Arrhythmias in Acute Myocardial Ischacmia. In Modern Trends in Cardiology, edited by MF Oliver. London, Buttcnvorths, pp 219-246, 1974 3. Case RB, Nasser MG, Crampton RS: Biochemical aspects of early myocardial ischemia. Am J Cardiol 24: 766-775, 1969 4. Parker JO, Chiong MA, West RO, Case RB The elTect of ischemia and alterations of heart rate on myocar...
متن کامل[Autophagy is involved in 6-OHDA-induced dopaminergic cell death].
OBJECTIVE To study the role of autophagy in the death of dopaminergic neurons induced by 6-hydroxydopamine (6-OHDA). METHODS Rat models of Parkinson disease (PD) were established by stereotaxic administration of 6-OHDA (8 μg) into the unilateral substantia nigra par compact (SNpc). Autophagosomes in the SNpc were observed with transmission electron microscopy (TEM), and the expression of auto...
متن کاملCardiac Sympathetic Denervation in 6-OHDA-Treated Nonhuman Primates
Cardiac sympathetic neurodegeneration and dysautonomia affect patients with sporadic and familial Parkinson's disease (PD) and are currently proposed as prodromal signs of PD. We have recently developed a nonhuman primate model of cardiac dysautonomia by iv 6-hydroxydopamine (6-OHDA). Our in vivo findings included decreased cardiac uptake of a sympathetic radioligand and circulating catecholami...
متن کاملTetrahydroxystilbene Glucoside Produces Neuroprotection against 6-OHDA-Induced Dopamine Neurotoxicity
Parkinson's disease (PD) was one of the most common neurodegenerative diseases with a slow and progressive loss of dopamine (DA) neurons in the midbrain substantia nigra (SN). Neuroinflammation was identified to be an important contributor to PD pathogenesis with the hallmark of microglia activation. Tetrahydroxystilbene glucoside (TSG) was the main active component extracted from Polygonum mul...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1985
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)63952-1